Title: Penetrating topical medicament

I claim:

1. A penetrating topical medicament, comprising:

from about 0.5 to 5% by volume of a member selected from the group consisting of the corticosteroids, derivatives of the corticosteroids, and mixtures thereof;

from about 10 to 35% by volume of a substance selected from the group consisting of methyl salicylate, triethanolamine salicylate, salicyamide, oil of eucalyptus menthol and mixtures thereof; and

from about 5 to 50% by volume of a medium for transporting said at least said member through the skin to a subcutaneous site.

2. The medicament as set forth in claim 1, including an agent selected from the group consisting of sodium lauryl sulfate, stearyl alcohol, cetyl alcohol, glycerol monostearate, polyethylene glycol, bentonite, tragacanth, and mixtures thereof.

3. The medicament as set forth in claim 1, said agent being present at a level of up to about 15% by volume.

4. The medicament as set forth in claim 1, including a rubefacient.

5. The medicament as set forth in claim 4, said rubefacient being camphor.

6. The medicament as set forth in claim 4, said rubefacient being present at a level of up to about 5% by volume.

7. The medicament as set forth in claim 1, said member being selected from the group consisting of hydrocortisone and derivatives thereof.

8. The medicament as set forth in claim 1, said medium being dimethyl sulfoxide.

9. The medicament as set forth in claim 1, said medium being a lower alcohol.

10. A penetrating topical medicament, comprising:

from about 5 to 90% by volume of dimethyl sulfoxide; and

from about 10 to 35% by volume of a member selected from the group consisting of methyl salicylate, triethanolamine salicylate, salicyamide and mixtures thereof.

Other info:


Inventors: Levy, Michael A. (9911 Campbell, Kansas City, MO, 64131)

Application Number: 06/271427
Filing Date: 1981-06-08
Publication_date: 1982-10-12
Assignee: Levy, Michael A.

Primary Class(es): 514/162 514/946, 514/164, 424/742, 514/936, 514/171
Other Classes: A61K31/57; A61K31/60; A61K47/20
US Patent Ref:

2801202	July, 1957	Poetsch	424/240
2815315	December, 1957	Pottier	424/240
2880130	March, 1959	Johnson	424/240
2880138	March, 1959	Johnson	424/240
2890152	June, 1959	Babcock, Jr. et al.	424/240
3019162	January, 1962	Brunner et al.	424/60
3053737	September, 1962	Johnson	424/240
3474168	October, 1969	Schayer	424/240
4012508	March, 1977	Burton	424/235

Other Refs: Other References: Merck Index, 9th Ed., (1976), p. 433.

Primary Examiner: Friedman, Stanley J.
Assistant Examiner:
Attorney: Schmidt, Johnson, Hovey & Williams