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Primary Examiner: Daus, Donald G.
Assistant Examiner: Eakin, M. C.
Attorney: Young & Thompson

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.alpha.-AMINOACYL CONTAINING NEW PEPTIDES WITH GASTRIN EFFECTS AND A PROCESS FOR THE PREPARATION THEREOF

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Title: Diphenylamine containing therapeutic composition and its applications, particularly in veterinary medicine

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Claims: Having now described my invention what I claim as new and desire to secure by Letters Patent is:

1. Process for the detoxification of a drug selected from the group consisting of carbon tetrachloride, hexachlorophene and bithionol sulfoxide in animals, comprising administering diphenylamine to an animal given said drug by the oral, subcutaneous, intramuscular or percutaneous route in an amount of 0.1-10 weight percent with respect to the weight of said drug.

2. Process as claimed in claim 1, wherein the diphenylamine is administered simultaneously with said drug.

3. Process as claimed in claim 1, wherein the diphenylamine and said drug are administered separately.

4. Therapeutic composition useful in veterinary medicine for the treatment of liver flukes, comprising a drug selected from the group consisting of carbon tetrachloride, hexachlorophene and bithionol sulfoxide and diphenylamine as a detoxicant in an amount of 0.1-10 weight percent with respect to the weight of said drug.

5. Composition as claimed in claim 6, in unit dosage form.

6. Process as claimed in claim 3, in which the diphenylamine is administered prior to said drug.
Other info:

Inventors: Baetz, Jacques L. E. (La Garenne Colombes, FR)

Application Number: 818836
Filing Date: 1977-07-25
Publication_date: 1979-10-23
Assignee: METABIO (Meudon la Foret, FR)
Primary Class(es): 514/658 424/663, 514/922
Other Classes:
US Patent Ref:
Other Refs: Other References: H. Gordon et al., Chemical Abstracts, 34:8049.sup.3, 1940.
Merck Veterinary Manual, Fourth Edition, (1973), pp. 702-704.
A. Mackie, et al., Chemical Abstracts, 49:11181a, (1955).
S. Zarinskaya, et al., Chemical Abstracts, 85:41000y, (1976).
A. Banting, et al., Chemical Abstracts, 83:157857w, (1975).
W. Spector (ed.), Handbook of Biological Data, 1956, pp. 506-508.
A. Banchetti, Chemical Abstracts, 50:15949d, 1956, Research on Anthelmintic Drugs.
J. Guthrie, Chemical Abstracts, 35:197.sup.9, 1941, Preliminary Observations on the Efficacy of Diphenylamine for the Removal of Intestinal Nematodes from Dogs.