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Primary Examiner: Schenkman, Leonard
Assistant Examiner:
Attorney: Boland; Thomas R.

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Title: Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes

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Claims: What is claimed is:

1. A method of therapeutically treating the symptoms of Sjogren's syndrome, ophthalmic edema and eye irritation in a mammal, comprising, topically administering to affected eyes of such mammal, a pharmaceutical composition which consists of a clear, water-miscible, physiologically acceptable, liquid composition which gels to a thickened, non-flowing and adhering consistency at human body temperature, the composition comprising an aqueous solution of a polyoxyethylenepolyoxypropylene block copolymer and having a gel transition temperature in the range of from about 25.degree. to about 40.degree. C.

2. A method according to claim 1 in which the pharmaceutical composition is applied to the affected eyes in drop form.

3. A method according to claim 1 in which the composition has a pH in the range of from about 6.2 to about 7.8.

4. A method of medicinally treating a mucous membrane condition in need of pharmacologic treatment comprising contacting such mucous membrane with a clear, water-miscible, physiologically acceptable, liquid composition which gels to a thickened, non-flowing and adhering consistency after contact with the mucous membrane, the liquid composition comprising a pharmacologically effective amount of a chemical material which is pharmacologically active against said condition, and a pharmaceutical vehicle which is a clear, water-miscible, physiologically acceptable liquid having a gel transition temperature in the range of from about 25.degree. to about 40.degree. C.

5. A method according to claim 4 in which the composition has a pH in the range of from about 6.2 to about 7.8.

6. A method according to claim 4 in which the pharmacologically active chemical material is dexamethasone.

7. A method according to claim 4 in which the pharmacologically active chemical material is pilocarpine HCl.

8. A method according to claim 4 in which the pharmacologically active chemical material is phenylephrine.

9. A method according to claim 4 in which the pharmacologically active chemical material is an antimicrobial agent.

10. A method according to claim 9 in which the pharmacologically active chemical material is selected from the group consisting of clofazimine, pimaricin, amphotericin, neomycin sulfate, chloramphenicol, bacitracin, sulfacetamide, gentamycin, and polymixin B sulfate.

11. A method according to claim 4 in which the liquid composition is applied to the mucous membrane in drop form.

12. A method of medicinally treating an eye condition in need of pharmacologic treatment comprising contacting the affected eye with a clear, water-miscible, physiologically acceptable, liquid composition which gels to a thickened, non-flowing adhering consistency after contact with the mucous membrane, the liquid composition comprising a pharmacologically effective amount of a chemical material which is pharmacologically active against said condition, and a pharmaceutical vehicle which is a clear, water-miscible, physiologically acceptable liquid having a gel transition temperature in the range of from about 25.degree. to about 40.degree. C.

13. A method according to claim 12 in which the composition has a pH in the range of from about 6.2 to about 7.8.

14. A method according to claim 12 in which the pharmacologically active chemical material is dexamethasone.

15. A method according to claim 12 in which the pharmacologically active chemical material is pilocarpine HCl and the eye condition is glaucoma.

16. A method according to claim 12 in which the pharmacologically active chemical material is phenylephrine.

17. A method according to claim 12 in which the pharmacologically active chemical material is an antimicrobial agent.

Other info:

Inventors: Krezanoski, Joseph Z. (Los Altos, CA, US)

Application Number: 661612
Filing Date: 1976-02-26
Publication_date: 1978-07-11
Assignee: Cooper Laboratories, Inc. (Parsippany, NJ)
Primary Class(es): 514/11 514/21, 514/31, 514/32, 514/39, 514/40, 514/155, 514/180, 514/250, 514/397, 514/628, 514/653
Other Classes:
US Patent Ref:

2921885	Jan, 1960	Bonchal	167/93.
3240709	Mar, 1966	Rankin	252/106.
3639574	Feb, 1972	Schmolka	424/78.
3740421	Jun, 1973	Schmolka	424/78.
3767788	Oct, 1973	Rankin	424/78.
3867533	Feb, 1975	Schmolka	424/78.
3882036	May, 1975	Krezanoski et al.	424/78.
3884826	May, 1975	Phare, Jr. et al.	424/78.
3947573	Mar, 1976	Rankin	424/78.

Other Refs: Other References: Wyandotte Corp., "The Wonderful World of Pluronic Polyols", (1973).