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Title: Novel di-(3'-hydroxyphenyl)-alkane compounds, process of preparation and their use in medicine



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Claims: What is claimed is:

1. A di-(3'-hydroxyphenyl)-alkane compound of the general formula (1) ##STR6## wherein R is a straight or branched alkyl of 1-6 carbon atoms and R' is hydrogen or methyl.

2. 3,4-di(3'-hydroxyphenyl)-hexane, in accordance with claim 1.

3. 2,3-di(3'-hydroxyphenyl)-butane, in accordance with claim 1.

4. 4,5-di-(3'-hydroxyphenyl)-octane, in accordance with claim 1.

5. A process of preparing the compound of claim 1, comprising reacting a compound of the formula (2) ##STR7## wherein R is a straight or branched alkyl of 1-6 carbon atoms and X is chlorine or bromine, with an alkyl magnesium halide of the general formula (3)

R -- Mg -- X (3) (3)

wherein R is a lower alkyl of 1-3 carbon atoms and X is chlorine, bromine or iodine, in the presence of waterfree cobaltous - (II) - or nickelous - (II) - chloride.

6. A process in accordance with claim 5 wherein the obtained dimerization product is then subjected to ether splitting.

7. A pharmaceutical composition for treatment of breast carcinoma comprising a compound in accordance with claim 1 in a breast-carcinoma-growth-inhibiting quantity and a pharmaceutical carrier.

8. A composition as in claim 7, in single dose form and comprising 10-300 mg of said compound.

9. A method for treating breast carcinoma in a mammal comprising orally, parenterally, or subcutaneously administering to said mammal a breast-carcinoma-growth-inhibiting amount of the compound of claim 1.
Other info:


Inventors: Schonenberger, Helmut (Unterhaching, DT)
Kranzfelder, Gerhard (Munich, DT)
Schmitt-Wallenborn, Helga (Munich, DT)

Application Number: 793321
Filing Date: 1977-05-03
Publication_date: 1978-06-13
Assignee: Klinge Pharma GmbH (Munich, DT)
Primary Class(es): 514/734 514/721, 568/644, 568/729
Other Classes:
US Patent Ref:
2382475Aug, 1945Gisvold260/619.
2400033May, 1946Tallman et al.260/619.
3934034Jan, 1976Manning424/346.

Other Refs: 236,169
Jun, 1945CH

Primary Examiner: Evans, Joseph E.
Assistant Examiner:
Attorney: Flocks; Karl W.