Title: Prolonged release drug form for the treatment of bovine mastitis

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Claims: We claim:

1. A bioerodable solid dosage form for the treatment of mastitis comprising from about 30 to 70% by weight of a dosage form of at least one antimicrobial agent intimately dispersed in a polyester of glycolic and lactic acid, prepared by heating the polyester to a temperature of about 60.degree.-80.degree. C, dispersing therein the antimicrobial agent and thereafter rapidly cooling the admixture, the polyester having a molecular weight less than 2,000, a glycolic acid content of about 60 to 80 mole percent, and a lactic acid content of about 20 to 40 mole percent.

2. The dosage form of claim 1 wherein the antimicrobial agent is chlortetracycline.

3. A dosage form for the treatment of mastitis comprising a suspension in a vegetable oil of about 30 to 50% by weight of the subdivided dosage form of claim 1.

Other info:

Inventors: Reuter, Gerald L. (Plattsburgh, NY, US)
Tsuk, Andrew G. (Plattsburgh, NY, US)

Application Number: 590358
Filing Date: 1975-06-25
Publication_date: 1977-03-08
Assignee: American Home Products Corporation (New York, NY)
Primary Class(es): 514/152 424/115, 424/116
Other Classes:
US Patent Ref:

3755558	Aug, 1973	Scribner	424/78.
3773919	Nov, 1973	Boswell et al.	424/78.
3887699	Jun, 1975	Yolles	424/78.

Other Refs:
Primary Examiner: Rosen, Sam
Assistant Examiner:
Attorney: Venetianer; Stephen