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Title: Method of treatment of nematode parasite infections in domestic animals



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Claims: I claim:

1. A method of treatment for the control of gastrointestinal nematode parasites in domestic animals infected with inhibited or inhibition-prone larvae of such parasites which comprises administering successively or concurrently from 1 microgram to 500 micrograms per kilogram of animal weight of a lactogenic substance and from 10 milligrams to 750 milligrams per kilogram of animal weight of an anthelmintic agent.

2. A method of treatment, as claimed in claim 1, for the control of gastrointestinal nematode parasites in domestic animals, which comprises administering prior to stabling time, successively or concurrently a lactogenic substance and an anthelmintic agent.

3. A method of treatment, as claimed in claim 2, for the control of gastrointestinal nematode parasites in sheep and cattle, which comprises administering prior to stabling time, successively or concurrently a lactogenic substance and an anthelmintic agent.

4. A method of treatment, as claimed in claim 3, for the control of gastrointestinal nematode parasites in sheep and cattle, which comprises administering, successively or concurrently, prior to stabling time, an estrogen and an anthelmintic agent.

5. A method of treatment, as claimed in claim 4 for the control of gastrointestinal nematode parasites in sheep and cattle which comprises administering successively or concurrently prior to stabling time, an estrogen selected from the group consisting of diethylstilbestrol, estrone, estradiol, estradiol diacylates, ethynylestradiol or mestranol, and an anthelmintic agent.

6. A therapeutic composition for the control of gastrointestinal nematode parasites in sheep and cattle, which comprises 1 .mu.g to 500 .mu.g/kg of animal weight of an estrogen and 10 mg to 750 mg/kg of animal weight of an anthelmintic agent, in the form of solutions or suspensions in pharmaceutically acceptable carriers.

7. A therapeutic composition as claimed in claim 6 for the control of gastrointestinal nematode parasites in sheep and cattle, which comprises 1 .mu.g/kg to 500 .mu.g/kg of animal weight of an estrogen selected from the group consisting of diethylstibestrol, estrone, estradiol, estradiol 3,17-diacylates, ethylnylestradiol and mestranol and 10 mg to 750 mg/kg of animal weight of an anthelmintic agent selected from the group, consisting of phenothiazine, thiabendazole, cambendazole, mebendazole, tetramisole, levamisole, pyrantel and methyridine, in the form of solutions or suspensions in pharmaceutically acceptable carriers.

Other info:


Inventors: Ayalew, Liyew

Application Number: 590781
Filing Date: 1975-06-26
Publication_date: 1977-02-22
Assignee:
Primary Class(es): 514/21
Other Classes:
US Patent Ref:
2971885Feb, 1961Luther et al.424/240.

Other Refs: Other References: Jones - Veterinary Pharmacology & Therapeutics - 3rd edit. (1965), p. 615.