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Primary Examiner: Medbery, Aldrich F.
Assistant Examiner:
Attorney: Alexander, Sell, Steldt & DeLaHunt

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Title: Ballistic inoculation of animals and projectile therefor

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Claims: What is claimed is:

1. A ballistic implant shaped for penetrating the epidermal covering of a living animal body and lodging totally within the tissues of the animal body, said implant consisting essentially of a biologically compatible polymer body and an antigen contained within the polymer body in a manner permitting release of said antigen in response to the fluids and cells of the living animal body.

2. A ballistic implant according to claim 1 wherein said antigen is contained within a cavity opening to the rear of said polymer body.

3. A ballistic implant according to claim 2 wherein said cavity is sealed by a removable cap.

4. A ballistic implant according to claim 1 which includes ballast means within the polymer body.

5. A ballistic implant according to claim 1 wherein said antigen is in a solid form.

6. A ballistic implant according to claim 1 wherein said polymer body is soluble in the fluids and cells of said living animal body.

7. A ballistic implant according to claim 6 wherein said antigen is distributed throughout the soluble polymer body.

8. A ballistic implant according to claim 6 wherein said soluble polymer body comprises hydroxypropyl cellulose.

9. A method of inoculating living animal bodies with an antigen, said method comprising ballistically implanting totally within the tissues of said animal body a ballistic shaped implant consisting essentially of a biologically compatible polymer body and an antigen contained within the polymer body whereby said antigen is released in situ in said animal body in response to the fluids and cells of said animal body.

10. A method according to claim 9 wherein said antigen is selected from the group consisting of vaccines, bacterins and toxoids.

11. A method according to claim 9 wherein said antigen is in a solid form.

12. A method according to claim 9 wherein said polymer body is soluble in the fluids and cells of said living animal body.

13. A method according to claim 12 wherein said polymer body comprises hydroxypropyl cellulose.

Other info:

Inventors: Krogseng, Gerald P. (Oakdale, MN, US)
Paul, Jr., Fred R. (Burnsville, MN, US)

Application Number: 524121
Filing Date: 1974-11-15
Publication_date: 1976-09-28
Assignee: Minnesota Mining and Manufacturing Company (St. Paul, MN)
Primary Class(es): 424/422 102/512, 604/500
Other Classes:
US Patent Ref:

251355	Dec, 1881	Gibbs	128/271.
979993	Dec, 1910	O'Byrne et al.	102/92.
2584166	Feb, 1952	Stevenson et al.	128/271.
2617359	Nov, 1952	VanHorn et al.	102/92.
2854925	Oct, 1958	Crockford et al.	102/92.
3122475	Feb, 1964	Schaeppi	128/271.
3344711	Oct, 1967	Mawhinney et al.	102/92.
3429263	Feb, 1967	Snyder et al.	102/92.
3520299	Jul, 1970	Lott et al.	128/217.
3538214	Nov, 1970	Polli et al.	424/19.
3616758	Nov, 1971	Komarov	102/92.
3857932	Dec, 1974	Shepherd	424/19.

Other Refs: Other References: "Final Report, Ballistic Delivery of Biological Reagents", Sept. 15, 1973, Sensory Systems Laboratory, Animal & Plant Health Inspection Service, U.S. Dept. of Agriculture, Contract 12-16-140-213-91, By Howard A. Baldwin et al.