Title: Ocular drug delivery device

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Claims: We claim:

1. In a sustained release ocular drug delivery device comprising a flexible body that is formed of a bioerodible polymeric material, sized and shaped for insertion in either cul-de-sac of the eye, and contains a drug, the improvement wherein the body has a stiffness and resistivity to bending manifested by a centroidal unsupported bending angle of less than 40.degree. during its drug dispensing lifetime.

2. The improvement of claim 1 wherein the centroidal unsupported bending angle is less than 20.degree. during said drug dispensing lifetime.

3. The improvement of claim 1 wherein said polymeric material is cross-linked gelatin.

4. The improvement of claim 1 wherein said body is 3 - 20 mm in length, 1 - 9 mm in width and 0.05 - 1 mm in thickness.

5. The improvement of claim 1 wherein the drug dispensing lifetime is in excess of one-half day.

6. The improvement of claim 1 wherein the drug dispensing lifetime is at least one day.

7. The improvement of claim 1 wherein the body is 3 - 20 mm in length, 1 - 9 mm in width and 0.05 - 1 mm in thickness and the drug dispensing lifetime is at least one day.

8. The improvement of claim 7 wherein the polymeric material is cross-linked gelatin.

Other info:

Inventors: Whitaker, Gordon W. (Palo Alto, CA, US)
Gad, Yigal (Mountain View, CA, US)

Application Number: 582948
Filing Date: 1975-06-02
Publication_date: 1976-06-15
Assignee: Alza Corporation (Palo Alto, CA)
Primary Class(es): 424/428
Other Classes:
US Patent Ref:

3626940	Dec, 1971	Zaffaroni	128/260.
3630200	Dec, 1971	Higochi	128/260.
3828777	Aug, 1974	Ness	128/260.

Other Refs:
Primary Examiner: Medbery, Aldrich F.
Assistant Examiner:
Attorney: Ciotti; Thomas E., Sabatine; Paul L., Mandell; Edward L.