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Primary Examiner: Rose, Shep K.
Assistant Examiner:
Attorney: Merriam, Marshall, Shapiro & Klose

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Title: Oral drug preparations

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Claims: I claim:

1. An oral drug preparation having a protracted effect and a substantially constant rate of release of the drug, comprising an admixture, of a drug and an effective amount of a buffer acid, buffer acid salts, and mixtures thereof, in the form of small spheroidal particles of 0.1 to 5 mm diameter, said particles having a coating thereon of a film-forming acrylic polymer drug-diffusing dragee lacquer, allowing for diffusion of the stomach and intestinal juices through the coating, but not being soluble in said juices.
Other info:

Inventors: Pedersen, Arne Martinus (Vanlose, DK)

Application Number: 608230
Filing Date: 1975-08-27
Publication_date: 1976-05-04
Assignee: A/S Alfred Benzon (Copenhagen, DK)
Primary Class(es): 424/497
Other Classes:
US Patent Ref:

2971889	Feb, 1961	Swintosky	424/31.
3247066	Apr, 1966	Milosovich	424/21.
3538214	Nov, 1970	Polli et al.	424/19.
3577512	May, 1971	Shepherd et al.	424/21.
3608063	Sep, 1971	Banker	424/22.
3629393	Dec, 1971	Nakamoto et al.	424/22.
3641237	Sep, 1972	Gould et al.	424/16.
3689634	Sep, 1972	Kliment et al.	424/21.
3775537	Nov, 1973	Lehmann et al.	424/21.

Other Refs: Other References: Lehmann, K. Pharm. Ind. 29(6): 396-398 (1967) Acrylic Resin Lacquers for Preparation of Depot Medicinal Forms.
Lehmann, K. et al. Pharm. Ind. 31(5): 319-322 (1969) Permeable Acrylic Resin Lacquers for Production of Medicinal Depot Forms II. (1).
Lehmann, K. et al. Pharm. Ind. 31(6): 409-412 (1969) Permeable Acrylic Resin Lacquers for Production of Medicinal Depot Forms II. (2).
Lehmann, K. et al. Drugs Made Ger. 16(4): 126, 131-132, 134, 136 (1973) Use of Aqueous Synthetic-Polymer Dispersions for Coating Pharmaceutical Dosage Forms.
Lehmann, K. et al. Labo-Pharma-Probl. Tech. 22 (228): 57-62, 65 (1974) Use of Aqueous Plastic Dispersions for Coating Pharmaceutical Forms.
Lehmann, K. Mfg. Chem. Aerosol News. 45(5): 48, 50 (1974) Polymer Coating of tablets. Versatile Technique.