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Primary Examiner: Rose, Shep K.
Assistant Examiner:
Attorney: Yetter; Jerry J., Filcik; Julius P., Witte; Richard C.

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Title: Compositions for topical application to animal tissue and method of enhancing penetration thereof

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Claims: What is claimed is:

1. A composition for application to animal tissue comprising a safe and effective amount of a anticholinergic scopolamine ester compound and from about 0.1% to about 10.0% of an aliphatic sulfoxide selected from the group consisting of octyl methyl sulfoxide, nonyl methyl sulfoxide, decyl methyl sulfoxide, undecyl methyl sulfoxide, dodecyl methyl sulfoxide, 2-hydroxydecyl methyl sulfoxide, 2-hydroxyundecyl methyl sulfoxide, and 2-hydroxydodecyl methyl sulfoxide.

2. The composition of claim 1 wherein the anticholinergic compound is selected from the group consisting of the free base and acid salt forms of a compound having the general structural formula: ##EQU3## wherein ##EQU4## is selected from the group consisting of a straight chain acyl group, a branched acyl group, an aromatic acyl group and a cyclic acyl group, containing from 4 to about 12 carbon atoms.

3. The composition of claim 1 wherein the anticholinergic compound is para-methoxybenzoyl scopolamine.
Other info:

Inventors: MacMillan, Francis S. Kilmer (Cincinnati, OH, US)
Lyness, Warren I. (Cincinnati, OH, US)

Application Number: 541901
Filing Date: 1975-01-17
Publication_date: 1976-04-27
Assignee: The Procter & Gamble Company (Cincinnati, OH)
Primary Class(es): 514/304 424/65, 514/708, 514/947
Other Classes:
US Patent Ref:

3312709	Apr, 1967	Kilmer-MacMillan	260/292.
3326768	Jun, 1967	Kilmer-MacMillan	424/265.
3527864	Sep, 1970	Kilmer-MacMillan et al.	424/337.
3678156	Jul, 1972	Kilmer-MacMillan et al.	424/68.
3839566	Oct, 1974	Kilmer-MacMillan et al.	424/337.
3903256	Feb, 1975	Kilmer-MacMillan et al.	424/59.

Other Refs: Other References: F. S. Kilmer-MacMillan et al., J. Invest. Dermat. 43(5):363- 377, Nov. 1964, "The Antiperspirant Action of Topically Applied Anticholinergics."