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Title: Anti-microbial compounds of 2', 4' substituted anilides of substituted nitrosalicylic acid for quadruped animals
Claims: I claim: 1. The method for treating a parasite infested or parasite exposed quadruped animal comprising administering orally to said animal an antiparasitically effective but nontoxic quantity of an active ingredient being a 3-tert.-butyl-6-methyl-5-nitrosalicylanilide of the general formula: ##SPC3## in which R.sub.1 is H, chloro, bromo, iodo, CF.sub.3 or alkyl of 1 to 4 carbon atoms, and R.sub.2 is chloro, bromo, iodo or CF.sub.3. 2. The method claim 1 in which the administration is of a curative quantity to a parasite infested animal. 3. The method of claim 1 in which the parasite is a Nematode or a Trematode and the quantity of active ingredient is chosen from about 0.25-50 mg./kg. based on the body weight of the host animal. 4. The method of claim 1 in which the parasite is a Haemonchus or a Fasciola; R.sub.1 is methyl, chloro, bromo, iodo or CF.sub.3 and R.sub.2 is chloro, bromo, iodo or CF.sub.3 ; and the quantity of active ingredient is chosen from about 0.5-10 mg./kg. based on the body weight of the host animal which is either sheep or cattle. 5. The method of claim 1 in which the parasite is a Fasciola; R.sub.1 is CF.sub.3 and R.sub.2 is bromo; and the quantity of active ingredient is chosen from about 0.5-10 mg./kg. based on the body weight of the host animal which is either sheep or cattle. 6. The method of claim 5 in which the parasite is Fasciola hepatica and the quantity of active ingredient is about 3 mg./kg. based on the body weight of the host animal. 7. The method of claim 5 in which the active ingredient is in the form of a drench, paste, bolus or top dressing. 8. A veterinary composition for antiparasitic use in a host quadruped animal comprising an orally ingestable carrier and admixed therein as an active ingredient an effective but nontoxic quantity of a 3-tert.-butyl-6-methyl-5-nitrosalicylanilide of the formula: ##SPC4## in which R.sub.1 is H, chloro, bromo, iodo, CF.sub.3 or alkyl of 1 to 4 carbon atoms, and R.sub.2 is chloro, bromo, iodo or CF.sub.3. 9. The veterinary composition of claim 8 in which said carrier contains a curative quantity of said active ingredient for a parasite infected host animal. 10. The composition of claim 8 in which the composition is for use against a Nematode or a Trematode and the effective but nontoxic quantity of active ingredient is chosen from about 0.25-50 mg./kg. based on the body weight of the host animal. 11. The composition of claim 8 in which the parasite is a Haemonchus or a Fasciola; R.sub.1 is methyl, chloro, bromo, iodo or CF.sub.3 and R.sub.2 is chloro, bromo, iodo or CF.sub.3 ; and the quantity of active ingredient is chosen from about 0.5-10 mg./kg. based on the body weight of the host animal which is either sheep or cattle. 12. The composition of claim 8 in which the parasite is a Fasciola; R.sub.1 is CF.sub.3 and R.sub.2 is bromo; and the quantity of active ingredient is chosen from about 0.5-10 mg./kg. based on the body weight of the host animal which is either sheep or cattle. 13. The composition of claim 12 in which the parasite is Fasciola hepatica and the quantity of active ingredient is about 3 mg./kg. based on the body weight of the host animal. 14. The composition of claim 12 in which the active ingredient is in the form of a drench, paste, bolus or top dressing. Other info: Inventors: Meek, William H. (Northfield, OH, US) Application Number: 465884 Filing Date: 1974-05-01 Publication_date: 1976-04-06 Assignee: Ferro Corporation (Cleveland, OH) Primary Class(es): 514/166 Other Classes: US Patent Ref:
Other Refs: Primary Examiner: Rosen, Sam Assistant Examiner: Attorney: Simmons; Milton L., Taylor; Wesley B. |
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