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Title: Method of inducing infertility in male animals and inhibiting the growth of the prostate
Claims: I claim: 1. A method of inhibiting fertility in male animals and of reducing the size of the prostate and the seminal vesicle in male animals which comprises orally administering to a male animal an effective non-toxic amount of a compound of the formula: ##EQU5## wherein X represents an anion of an acid having an ionization constant of at least 1 .times. 10.sup.-.sup.7, R.sub.1, R.sub.2 and R.sub.3 are alkyl having one to 36 carbon atoms, aryl having six to 10 carbon atoms, or alkyl aryl having seven to 12 carbon atoms, R.sub.4 is hydrogen, alkyl having one to 36 carbon atoms, aryl having six to 10 carbon atoms or alkyl aryl having seven to 12 carbon atoms, and ##EQU6## are each pyrrolidino. 2. The method of claim 1 wherein the acid is hydrochloric acid. 3. The method of claim 1 wherein the acid is nitric acid. 4. The method of claim 1 wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are alkyl. 5. The method of claim 1 wherein ##EQU7## are each pyrrolidino. 6. The method of claim 4 wherein the compound is 3,5-bis(dimethylamino)-1,2,4-dithiazolium chloride. 7. The method of claim 1 wherein the compound is 3-dimethylamino-5-methylimino-1,2,4-dithiazolidine hydrochloride. Other info: Inventors: Settepani, Joseph A. (Somerville, NJ, US) Application Number: 381963 Filing Date: 1973-07-23 Publication_date: 1976-01-13 Assignee: Ortho Pharmaceutical Corporation (Raritan, NJ) Primary Class(es): 514/360 Other Classes: US Patent Ref:
Other Refs: Other References: Chemical Abstracts 78: 24473t (1973). | |