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Title: Cyclopropyl substituted polyenes

Abstract: There is disclosed certain cyclopropyl substituted polyenes useful for treating dermatoses such as acne, psoriasis and epithelial cancers.


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Inventors: Wright, John J. (Cedar Grove, NJ)

Application Number: 06/450624
Filing Date: 1982-12-17
Publication_date: 1984-02-14
Assignee: SCHERING CORP (US)

Primary Class(es): 514/572 562/500, 564/188, 514/887, 514/531, 560/118, 514/861,
Other Classes: C07C61/18; C07C69/74; A61K31/19; A61K31/215
US Patent Ref:
3950418April, 1976Bollag et al.424/320Vitamin A acid amides
4126698November, 1978Gander et al.424/305Retinoic acid derivatives in the treatment of acne
4190594February, 1980Gander et al.424/305Retinoic acid derivatives
4304787December, 1981Gander et al.424/305Benzyl all-trans-retinoate used for the treatment of acne

Other Refs: BE762344
February, 1971424/317
Other References: Journal of Medicinal Chemistry, vol. 25, No. 11, pp. 1269-1277 (1982), Pawson et al., "Retinoids at the Threshold: Their Biological Significance and Therapeutic Potential".

Primary Examiner: Trousof, Natalie
Assistant Examiner: Scott, Patricia M.
Attorney: Rosen, Gerald S.
Eisen, Bruce M.
Claims: