Title: Platinum(IV)-diamine complexes, a process for the preparation thereof, a process for the preparation of a medicine using such a platinum(IV)-diamine complex for the treatment of malignant tumors in mice

Abstract: Platinum(IV)-diamine-complexes, a process for the preparation thereof, a process for the preparation of a medicine using such a platinum(IV)-diamine-complex for the treatment of malignant tumors in mice as well as the shaped medicine thus obtained.

This invention relates to novel platinum-diamine complexes, a pharmaceutical composition using the novel complexes and methods of treating malignant tumors in mice using the pharmaceutical composition.

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Inventors: Bulten, Eric J. (Bilthoven, NL)
Verbeek, Francois (Harmelen, NL)

Application Number: 06/232298
Filing Date: 1981-02-06
Publication_date: 1984-02-14
Assignee: Tno (NL)

Primary Class(es): 514/492 556/137, 987/11
Other Classes: C07F15/00; A61K31/28; C07F15/00
US Patent Ref:

4053587	October, 1977	Davidson et al.	424/131	Method of treating viral infections
4119654	October, 1978	Tobe et al.	260/429R	Compositions containing platinum
4140707	February, 1979	Cleare et al.	260/429R	Malonato platinum anti-tumor compounds
4228090	October, 1980	Hydes et al.	260/429R	Compositions containing platinum
4250189	February, 1981	Hydes et al.	260/429R	Compositions containing platinum

Other Refs: Other References: Braddock et al., Chemico-Biological Interactions, vol. 11, No. 3, pp. 158-159 (1975).
Van Kralingen, C. G., Antitumor Platinum Compounds; Synthesis, Structure and Biological Activity, No. 7, 1979.
B. Rosenberg and L. Van Camp, Cancer Research 30 (1970) 1799-1802.
A. P. Zipp and S. G. Zipp, J. Chem. Ed., 54 (12) (1977) p. 739.
M. L. Tobe and A. R. Khokhar, J. Clinical Hematol. Oncol., 7 (1) (1977), pp. 114-134.
Appleton, T. C. and Hall, J. R., Inorganic Chemistry, vol. 11, No. 1, 1972, pp. 112-117.

Primary Examiner: Sneed, Helen M. S.
Assistant Examiner:
Attorney: Brumbaugh, Graves, Donohue & Raymond

Parent Case Data:

This is a continuation-in-part application of application Ser. No. 213,065 filed De