Title: 2-[4-[(4,4 -Dialkyl-2,6-piperidinedion-1-yl)butyl]-1-piperazinyl]pyrimidines

Abstract: 1-[4-(4,4-Dialkyl-2,6-piperidinedion-1-yl)butyl]piperazines with 2-pyrimidyl substituents in the 4- position have been synthesized and demonstrate useful anxiolytic properties. The compound 4,4-dimethyl-1-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-2,6-piperidinedi one, which has selective anxiolytic activity, constitutes the preferred embodiment of the invention.

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Inventors: Temple Jr., Davis L. (Evansville, IN)

Application Number: 06/334688
Filing Date: 1981-12-28
Publication_date: 1983-12-27
Assignee: MEAD JOHNSON & CO (US)

Primary Class(es): 514/252.180 544/299, 544/230, 544/309, 544/298, 544/389,
Other Classes: C07C51/00; C07D211/88; C07D211/90; C07D239/42; C07D239/46; C07D239/56; C07D309/32; C07D401/12; C07D487/10US Patent Ref:

3398151 August, 1968 Wu et al. 424/250 Azaspirodecanediones and azaspiroundecanediones
3717634 February, 1973 Wu et al. 544/295
3907801 September, 1975 Wu et al. 544/295 N-?(4-pyridyl-piperazino)-alkyl!-azaspiroalkanediones
3976776 August, 1976 Wu et al. 424/251 Tranquilizer process employing N-(heteroarcyclic)piperazinylalkylazaspiroalkanediones
4182763 January, 1980 Casten et al. 424/251 Buspirone anti-anxiety method

Other Refs: GB2023594

January, 1980

Other References: Wu et al., "Journal Medicinal Chemistry", vol. 15, (5), 1972, pp. 477-479.
Wu et al., "J. Med. Chem.", vol. 12, (4), 1969, pp. 876-881.
Pollard et al., "J. Org. Chem.", vol. 24, (6), 1959, pp. 764-767.
Benica et al., "J. Amer. Pharm. Assoc.", 1950, pp. 451-456.

Primary Examiner: Daus, Donald G.
Assistant Examiner: Turnipseed, James H.
Attorney: Ryan, Richard P.
Uloth, Robert H.

Claims: