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Title: Antiallergic and antiulcer 1-oxo-1H-thiazolo[3,2-a]pyrimidine-2-carboxamides and intermediates therefor

Abstract: Antiallergy and antiulcer agents having the formula (I), ##STR1## and their pharmaceutically acceptable salts, wherein R1 and R2 taken separately are each hydrogen or lower alkyl; and R1 and R2 taken together are alkylene of 3-9 carbon atoms or phenylalkylene of 9-11 carbon atoms, with the proviso that the ring so formed is between 5- and 8-membered; acids of the formula (II), ##STR2## wherein R1 and R2 are as defined above and R3 is hydrogen, which are useful as intermediates for compounds of the formula (I), but in many instances also possess the same useful biological activity as do formula I compounds; and intermediates of the formula II wherein R1 and R2 are defined as above, and R3 is alkyl of 1 to 4 carbon atoms, carbalkoxy of 2 to 5 carbon atoms, carbophenoxy or carbobenzoxy, are also described.


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Inventors: Kadin, Saul B. (New London, CT)

Application Number: 06/312372
Filing Date: 1981-10-19
Publication_date: 1983-12-27
Assignee: Pfizer (US)

Primary Class(es): 514/259.200 544/250, 514/926, 514/267, 514/927, 544/278
Other Classes: C07D277/40; C07D277/42; C07D277/60; C07D277/82; C07D513/04; C07D277/00; C07D513/00; A61K31/505
US Patent Ref:
4041163August, 1977Bindra et al.424/251
4152448May, 1979Wardell424/283

Other Refs:
Primary Examiner: Waddell, Frederick E.
Assistant Examiner:
Attorney: Connolly, And Hutz
Parent Case Data: CROSS REFERENCE TO RELATED APPLICATION

This application is a division of application Ser. No. 9