Title: Propanolamine derivatives

Abstract: Propanolamine derivatives of the formula: ##STR1## wherein R² is CH₃ SO or CH₃ SO₂ ;

R³ is hydrogen, methyl or methoxy; or

R² and R³ are together --S(O)_m (CH₂)₄ --when S is attached at R² or --(CH₂)_n S(O)_m -- when S is attached at R³ (where m=1 or 2 and n=3 or 4);

R⁴ is hydrogen or alkyl C₁-4 ;

Z is --(CH₂)₂ -- or ##STR2## and their non-toxic salts. Processes for the preparation and pharmaceutical compositions thereof. The compounds exhibit both β-adrenoreceptor antagonist activity and vasodilator activity and are indicated for use in the treatment of hypertension.

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Inventors: Baxter, Andrew J. G. (Shepshed, GB2)
Myers, Malcolm (Hull, GB2)

Application Number: 06/277610
Filing Date: 1981-06-26
Publication_date: 1983-10-18
Assignee: RECKITT & COLMANN PROD LTD (GB)

Primary Class(es): 514/431 514/432, 514/651, 549/23, 564/349, 549/9
Other Classes: C07C317/22; C07D335/06; C07D337/08; C07C317/00; C07D335/00; C07D337/00; A61K31/135
US Patent Ref:

3723524	March, 1973	Augstein et al.	564/349	POLAR-SUBSTITUTED PROPANOLAMINES AS ANTI-ANGINA AND ANTI-HYPERTENSIVE AGENTS
4067904	January, 1978	Comer et al.	564/349	Alkylsulfonylphenoxypropanolamine derivatives
4165384	August, 1979	Carlsson et al.	564/349	Amide substituted phenoxy propanol amines

Other Refs: GB1245148GB1544872

September, 1971	564/165
April, 1979

Other References: Drugs of the Future, vol. V, No. 2, (1980), pp. 87-89.
Drugs of the Future, vol. 1, (1976) pp. 38-42.
Augstein et al., J. Med. Chem., vol. 16, No. 11 (1973) pp. 1245-1251.
Smith, et al., J. Med. Chem., vol. 20(12) 1653 (1977).

Primary Examiner: Wiseman, Thomas G.
Assistant Examiner: Pepper, Frederick W.
Attorney: Bacon & Thomas

Claims:

We claim: