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Title: Platinum-diamine complexes, a method for the preparation of a medicine using such a platinum-diamine complex for the treatment of malignant tumor in mice

Abstract: This invention relates to novel platinum-diamine complexes having the formula: ##STR1## wherein R1 and R2 independently of each other may be selected from the group consisting of hydrogen, an alkyl group having 1-20 carbon atoms, a cycloalkyl group having from 3-7 carbon atoms in the ring, an aralkyl group, and an aryl group having 1-20 carbon atoms, whereas R1 and R2 together may form a cycloalkyl group having 3-7 carbon atoms in the ring and having the formula: ##STR2## wherein N is 2 to 7 and wherein R3 and R4 independently of each other are selected from the group consisting of hydrogen, an alkyl group having 1-20 carbon atoms, an aryl group or an aralkyl group having 1-20 carbon atoms in the alkyl group and X is an anionic group, providing that when X is either chlorine or malonate, R1, R2, R3 and R4 are not each H; when X is chlorine and R1 and R2 are each H, R3 and R4 are not each methyl; when X is chlorine and R1 and R2 are each methyl, R3 and R4 are not each H, and when X is chlorine R1 is hydrogen and R2 is methyl and R3 and R4 are not each hydrogen.


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Inventors: Berg, Jan (Nieuwegein, NL)
Verbeek, Francois (Harmelen, NL)
Bluten, Eric J. (Blaricum, NL)

Application Number: 06/287531
Filing Date: 1981-07-27
Publication_date: 1983-10-18
Assignee: Tno (NL)

Primary Class(es): 514/492 556/137, 556/40, 987/11
Other Classes: C07F15/00; A61K31/28; C07F15/00
US Patent Ref:
3892790July, 1975Tobe et al.260/429RCompositions containing platinum
3904663September, 1975Tobe et al.260/429RCompositions containing platinum
4140707February, 1979Cleare et al.260/429RMalonato platinum anti-tumor compounds

Other Refs: Other References: Appleton, T. G.; Hall, J. R., Inorganic Chemistry, vol. 11, No. 1, p. 112, 1972.
Appleton, T. G., Hall, J. R., Inorganic Chemistry, vol. 9, No. 8, p. 1800, 1970.
Chemical Abstracts, vol. 80, p. 4, ref. 66593d.
Chemical Abstracts, vol. 87, 1977, p. 11, ref. 15694z.
Chemical Abstracts, vol. 87, ref. 145547q, p. 14.
Chemical Abstracts, vol. 78, 1973, p. 10, ref. 105899p.
Bioinorg. Chem. 2, 187-210, (1973).
Platinum Metal Reviews 17, 2-13, (1973).
Cleare, M. J. and Hoeschele, J. D., Platinum Metals Rev. 17, (1), 1973.

Primary Examiner: Sneed, Helen M. S.
Assistant Examiner:
Attorney: Brumbaugh, Graves, Donohue & Raymond
Parent Case Data:

This application is a continuation-in-part of application Ser. No. 054,891 filed Ju