Title: Process to produce anthracycline glycosides

Abstract: There is presented a process for producing anthracycline glycosides A by converting the sugar moiety of anthracycline glycosides B, represented by the following formula: ##STR1## into the sugar moiety of anthracycline glycosides A, represented by the following formula: ##STR2## with the aid of a microorganism belonging to the species Streptomyces galilaeus or Streptomyces melanogenes.

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Inventors: Fujiwara, Akiko (Kamakura, JP)
Hoshino, Tatsuo (Kamakura, JP)
Sekine, Yuzuru (Yokohama, JP)

Application Number: 06/313066
Filing Date: 1981-10-19
Publication_date: 1983-05-10
Assignee: Hoffmann, Roche LA.

Primary Class(es): 435/78 435/886
Other Classes: C07H15/252; C12P19/56; C07H15/00; C12P19/00; C12R1/465; C12P19/56
US Patent Ref:

4329339

May, 1982

Fujiwara et al.

435/78

Anthracyclinones and derivatives thereof

Other Refs: Other References: Journal of Antibiotics, vol. 32, pp. 472-481, (May 1979).
Umezawa et al, The Journal of Antibiotics, (Japan), vol. 28, No. 10, pp. 830-835, (Oct. 1975).

Primary Examiner: Shapiro, Lionel M.
Assistant Examiner:
Attorney: Saxe, Jon S.
Leon, Bernard S.
Hoffman, Frank P.

Claims: