Title: Process for the production of human luteinizing hormone

Abstract: The present invention relates to a process for the production of human luteinizing hormone (hLH).

More precisely, the invention relates to a process for the mass production of hLH, comprising in vivo multiplication of human cells capable of producing hLH, using non-human warm-blooded animal, and exposure of the multiplied human cells to a luteinizing hormone inducer.

The hLH production according to the invention is extremely higher, in terms of hLH production per cell, than that attained by conventional processes using in vitro tissue culture, thus, hLH can be used in a sufficient amount in the prevention and treatment of human diseases.

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Inventors: Sugimoto, Kaname (Okayama, JP)

Application Number: 06/290862
Filing Date: 1981-08-07
Publication_date: 1983-05-10
Assignee: Hayashibara, Biochem Lab (JP)

Primary Class(es): 435/70.200 435/70.300, 530/399
Other Classes: C07K14/59; A61K38/00; C07K14/435; C12P21/02; C12P21/00; C12P21/04
US Patent Ref:

4276282	June, 1981	Sugimoto et al.	Interferon and preparations containing interferon
4285929	August, 1981	Sugimoto et al.	Type II interferon and agents thereof
4288546	September, 1981	Narasimhan et al.	435/70	Process for the large scale production of pituitary hormones by serial secondary suspension culture
4328207	May, 1982	Sugimoto	Process for preparing mouse interferon

Other Refs: Other References: Chemical Abstracts, 91:86930s (1979).

Primary Examiner: Rosen, Sam
Assistant Examiner:
Attorney: Browdy, And Neimark

Claims:

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