Title: Indolizine derivatives and process for preparing the same

• Summary
• Claims
• Description
• View all

Abstract: Novel indolizine derivatives represented by the general formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein: R represents an alkyl radical having from 1 to 8 carbon atoms, or a phenyl group non-substituted or bearing one or two substituents, selected from halogen atoms and from lower alkyl and alkoxy groups,

X₁ represents hydrogen, chlorine, bromine, iodine, methyl or methoxy,

A represents a group selected from: ##STR2## in which X₂ represents hydrogen, chlorine, bromine, iodine, methyl or methoxy and X₃ represents hydrogen, chlorine, bromine, iodine or methyl,

R₁ represents a methyl, ethyl, n-propyl or n-butyl radical,

n represents an integer in the range of 2 to 6 inclusive,

with the proviso that when both X₂ and X₃ represent hydrogen or methyl, X₁ is other than hydrogen.

They are effective for treating pathological syndromes of the heart and particularly angina pectoris and cardiac arrhythmias.