Title: Heterocyclic compounds

• Summary
• Claims
• Description
• View all

Abstract: Compounds of the formula ##STR1## wherein Het is ##STR2## n is an integer from 1 to 4, inclusive, preferably 2 or 3, R₁ is H or acyl,

R₂ is H, R₁ O, --NHSO₂ R₇, --NHCOR₈, --NHCONHR₈, --NH--CH₂ --C₆ H₄ --R₉, --CH₂ OH, --CH₂ SO₂ R₇, --CONHR₈, halogen or --CN,

R₃ is H, halogen, R₇ or --OR₇,

R₂ and R₃ together with each other are ##STR3## R₄ is H, --CH₃ or --C₂ H₅, R₅ and R₆ are each H or --CH₃,

R₇ is C₁ -C₄ alkyl,

R₈ is H or C₁ -C₄ alkyl,

R₉ is H, C₁ -C₄ alkyl or C₁ -C₄ alkoxy optionally interrupted by oxygen,

R₁₀ and R₁₂ are each H, CH₃, Cl or OCH₃, or together methylenedioxy,

X is ##STR4## or N, and Z is --CH₂ or --CO;

in the form of racemates, enantiomers, diastereoisomeric antipode pairs, and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as the salts are useful as bronchospasmolytics, spasmolytics, muscle-relaxants, antiallergics and hypotensives.