Title: Theophyllinylmethyldioxolane derivatives, methods for their preparation and pharmaceutical compositions containing them

Abstract: Compounds of the following general formula ##STR1## wherein: X and Y are different from each other and represent --CH₂ -- or an oxygen atom; R represents a radical selected from hydroxy, bromo, acetoxy, pyrrolidino, morpholino, piperazino and piperazino substituted at the position 4 by a carbethoxy, benzyl, phenyl, halophenyl, methoxyphenyl or trifluoromethylphenyl group, or when X is --CH₂ -- and Y is an oxygen atom, R may represent also chloro; methods for their preparation; pharmaceutical compositions containing them. The compounds possess a remarkable antitussive activity.

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Inventors: Chiodoni, Ugo (Milan, IT)
Franzone, Jose S. (Turin, IT)
Spinelli, Silvano (Trecate, IT)

Application Number: 06/251485
Filing Date: 1981-04-06
Publication_date: 1983-03-29
Assignee: Abc, Ist Biolog Chem Spa (IT)
Unibios, Spa (IT)

Primary Class(es): 514/234.200 514/252.160, 544/271, 544/118, 514/850, 514/2
Other Classes: C07D473/08; C07D473/00; A61K31/52; A61K27/00; C07D473/00
US Patent Ref:

2761861	September, 1956	Doebel et al.	544/267	Process for the manufacture of novel xanthine bases and salts thereof
2840559	June, 1958	Krantz, Jr. et al.	544/267	Nuclearly substituted 8-theophyllines and method of making the same
3734911	May, 1973	Bestian	544/271

Other Refs: FR1523273

March, 1968

544/267

Other References: Chem. Abstracts 61: 662b.

Primary Examiner: Love, Ethel G.
Assistant Examiner:
Attorney: Bucknam, And Archer

Claims:

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