Title: Benzothiazinopyrazoles having pharmacological activity

Abstract: 1,2 Benzothiazino[3,4-d]pyrazoles of the following general formula ##STR1## wherein R stands for a linear or branched (C₂-4) alkyl chain bearing a substituent of formula ##STR2## in which the R" radicals may be the same or different and represent hydrogen, (C₂-4)alkyl, (C₄-7) cycloalkyl or, taken together with the adjacent nitrogen atom, may also represent a saturated, 5 to 7 membered heterocyclic ring containing from one to three heteroatoms independently selected from O,N and S, or R may represent the 1-ethyl-pyrrolidine-2-yl-methyl radical, and R' is hydrogen, a halogen atom or a (C₁-4) alkyl radical; methods for their preparation; pharmaceutical compositions containing them. The compounds possess antiinflammatory, antipyretic and analgesic activity.

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Inventors: Del, Bono Rinaldo (Milan, IT)

Application Number: 06/279455
Filing Date: 1981-07-01
Publication_date: 1983-03-29
Assignee: Mediolanum, Farmaceutici Srl (IT)

Primary Class(es): 514/211.150 514/217.050, 514/211.080, 544/33, 514/916, 51
Other Classes: C07D279/02; C07D513/04; C07D279/00; C07D513/00; A61K31/54; C07D513/04
US Patent Ref:

3346572	October, 1967	Shavel et al.	544/33	Pyrazolo [4, 3-c] [1, 2] benzothiazine 5, 5-dioxides and process for their production
3925371	December, 1975	Rasmussen	544/49	Benzothiazine-1,1-dioxides

Other Refs:
Primary Examiner: Ford, John M.
Assistant Examiner:
Attorney: Bucknam, And Archer

Claims:

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