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Title: Process for producing plasminogen activator

Abstract: In the production of plasminogen activator from animal cells in a nutrient solution, the addition of a large amount of fumaric acid, malic acid, succinic acid, and/or glycolic acid to the nutrient solution brings about a 30 to 180% increase in the amount of plasminogen activator produced.


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Inventors: Horiguchi, Sadayuki (Fuji, JP)
Hasegawa, Akio (Fuji, JP)
Sakamoto, Hajimu (Fuji, JP)

Application Number: 06/097284
Filing Date: 1979-11-26
Publication_date: 1982-05-04
Assignee: ASAHI CHEMICAL IND

Primary Class(es): 435/212 435/212
Other Classes: C12N9/72; C12N9/48
US Patent Ref:
4232124November, 1980Mann435/215Method of producing plasminogen activator

Other Refs:
Primary Examiner: Shapiro, Lionel M.
Assistant Examiner:
Attorney: Sughrue, Mion Zinn Macpeak And Seas
Claims: