Title: Biological cell parameter change test method and apparatus

Abstract: By subjecting cells, such as blood cells, tissue cells, and bone marrow cells, to hypotonic solutions having different osmolalities, the cells will rapidly attain a change in volume and electrical resistance parameters, which change is measurable, for example, by a Coulter Counter® particle measuring instrument. The relationship between change in cell resistance or cell volume and osmolality provides a discriminator between normality, different diseases, and certain inherited differences.

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Inventors: Shine, Ian B. (Lexington, KY)

Application Number: 06/118727
Filing Date: 1980-02-05
Publication_date: 1981-07-14
Assignee: COULTER ELECTRONICS

Primary Class(es): 324/71.100 324/71CP
Other Classes: G01N33/487; G01N27/00
US Patent Ref:

2656508	October, 1953	Coulter	324/71CP	Means for counting particles suspended in a fluid
3259842	July, 1968	Coulter et al.	324/71CP	Particle analyzing device
3982183	September, 1976	Collineau et al.	324/71CP	Particle sizing apparatus
4041385	August, 1977	Gulliford et al.	324/71CP	On-line sampling system for monitoring particles suspended in a fluid

Other Refs:
Primary Examiner: Tokar, Michael J.
Assistant Examiner:
Attorney: Hibnick, Gerald R.

Claims:

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