Title: Preparation of blood fraction

Abstract: Concentrates of one of the coagulation factors II, V and VIII or a mixture thereof or blood plasma free from one or more of the coagulation factors VII, IX, X, XI and XII can be prepared by adding a reducing substance comprised of dithiothreitol, dithioerythritol, lipoic acid, mercaptoethanol, or a borohydride to blood or plasma, dithiothreitol being preferred. The amount of reducing substance and the period of time for interaction are so adapted to obtain the product desired, whereafter the blood and plasma, respectively, are optionally fractionated in a known manner.

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Inventors: Blomback, Birger E. G. (Stockholm, SE)
Hessel, Dagny B. (S-162 41 Vallingby, SE)

Application Number: 005877
Filing Date: 1979-01-23
Publication_date: 1980-10-21
Assignee:
Primary Class(es): 530/381 514/8, 514/21, 514/802, 530/383, 530/384, 530/830, 530/831
Other Classes:
US Patent Ref:

3920625

Nov, 1975

Andersson et al.

424/101.

Other Refs:
Primary Examiner: Waddell, Frederick E.
Assistant Examiner:
Attorney: Cushman, Darby & Cushman