Title: Oral composition for improving oral health

Abstract: A therapeutic composition is disclosed for use in improving the physiological tone of the oral tissues, which among other beneficial effects nourishes said tissues and causes them to approach normal condition. The therapeutic composition also has an antimicrobial effect on the oral microflora including those difficult to eliminate pathogenic genera known to be implicated in dental caries and periodontal disease. The therapeutic composition comprises a pharmaceutically acceptable, water soluble zinc salt and ascorbic acid or an active analog thereof. The zinc salt and the ascorbic acid are present in an amount sufficient to provide a synergistic combination which has a greater than additive antimicrobial effect on such oral genera as Actinomyces, Streptococcus, Staphylococcus, Candida, Pseudomonas and Escherichia.

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Inventors: Fahim, Mostafa S. (Columbia, MO, US)
Miller, Ercell L. (Columbia, MO, US)

Application Number: 935247
Filing Date: 1978-08-21
Publication_date: 1980-10-21
Assignee:
Primary Class(es): 424/49 424/642, 514/474
Other Classes:
US Patent Ref:

1488097	Mar, 1924	Greger	424/145.
2470906	May, 1949	Taylor	424/55.
3065139	Nov, 1962	Ericsson et al.	424/130.
3772431	Nov, 1973	Mlkvy et al.	424/49.
3886265	May, 1975	Evers et al.	424/49.
3888976	Jun, 1975	Mlkvy et al.	424/49.
4022880	May, 1977	Vinson et al.	424/49.

Other Refs: 7102423

Aug, 1972	NL

Primary Examiner: Robinson, Douglas W.
Assistant Examiner:
Attorney: Fishel; Grace J.