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Primary Examiner: Robinson, Allen J.
Assistant Examiner:
Attorney: Seidel, Gonda, Goldhammer & Panitch

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Title: Ornithine and arginine salts of branched chain keto acids and uses in treatment of hepatic and renal disorders

Abstract: Novel compounds are prepared by reacting ornithine or arginine with alpha keto analogs of branched chain essential amino acids, namely valine, leucine and isoleucine. The compounds are useful either individually or as a mixture in the treatment of hepatic disorders which are characterized by hyperammonemia and portal systemic encephalopathy. Use of these compounds in treatment of renal failure also appears promising.

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Inventors: Walser, Mackenzie (Ruxton, MD, US)

Application Number: 887570
Filing Date: 1978-03-17
Publication_date: 1980-10-14
Assignee: The Johns Hopkins University (Baltimore, MD)
Primary Class(es): 562/560 562/561
Other Classes:
US Patent Ref:

3441650	Apr, 1969	Georges	260/501.
3950529	Apr, 1976	Fischer et al.	424/273.
4100293	Jul, 1978	Walser	424/274.

Other Refs: 8144831432756827M222699346-31941034358

Jun, 1969	CA.
Feb, 1966	FR.
Apr, 1967	FR.
Nov, 1974	FR.
Jan, 1971	JP
Jun, 1966	GB.

Other References: Matsuzawa; J. Biochemistry, 75:601-609 (1974).
Chainuvati et al.; Acta Hepato-Gastroenterol, 24(1977) 434-439.
Rognstad; Biochimica et Biophysica Acta 496, 249-254 (1977).
Kisfaludy; Mat. Med. Nordm. 29(1977) pp. 315-325.
Molimard et al; III. Internationales Ammonich Symposium (1977) pp. 200-206.
Muting et al.; Munchener Medizinische Wochenschrift, 1977, pp. 1-12.