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Primary Examiner: Marantz, Sidney
Assistant Examiner:
Attorney: Patton; Walter, Raines; Stephen, Graddis; Albert H.

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Title: Removal of heparin from heparin-containing blood plasma samples using a triethylaminoethyl cellulose tablet

Abstract: A tableted form of fibrous triethylaminoethyl cellulose suitable for the removal of heparin from heparin-containing blood plasma. The tablet is composed of granular microcrystalline cellulose and fibrous triethylaminoethyl cellulose in a ratio of from about 5.4:1 to about 10:1. The triethylaminoethyl cellulose tablet, which is formulated to provide from about 5 to about 26 mg. of triethylaminoethyl cellulose per milliliter of plasma sample, is added to a heparin-containing blood plasma sample, the sample is agitated or allowed to stand for a time sufficient to permit adsorption of substantially all heparin present. The sample is then centrifuged and the remaining heparin-free plasma can be subjected to coagulation testing in order to determine the true clotting time.

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Inventors: Butler, James R. (Morris Plains, NJ, US)
Turner, James E. (Morristown, NJ, US)
Goodhart, Frank W. (Morristown, NJ, US)

Application Number: 050355
Filing Date: 1979-06-20
Publication_date: 1980-10-07
Assignee: Warner-Lambert Company (Morris Plains, NJ)
Primary Class(es): 436/175 536/21
Other Classes:
US Patent Ref:

2128432	Aug, 1938	Ramage	252/427.
2687990	Aug, 1954	Weisz	252/427.
3099600	Jul, 1963	Toccaceli	536/21.
4055510	Oct, 1977	Peska	252/426.
4122250	Oct, 1978	Schmer	536/21.

Other Refs: 1195010

Jun, 1965	DE

Other References: Chemical Abstracts, 78:112325b (1973).
Nealon et al., "An Extracorporeal Device to Treat Barbiturate Poisoning," JAMA, Jul. 1966, vol. 197, No. 2, 158-160.
Thompson et al., "Removal of Heparin and Protamine from Plasma," J. Lab. Clin. Med., 88, 922-929 (Dec. 1976).