Title: 1-[(Heterocyclyl)-alkyl]-4-diarylmethoxy piperidine derivatives

Abstract: Novel 1-[(heterocyclyl)alkyl]-4-diarylmethoxy piperidine derivatives are disclosed having the formula ##STR1## where n is 2-6, Ar.sup.1 and Ar.sup.2 are aryl and B is a substituted benzimidazolyl radical. These compounds are useful for their antianaphylactic and antihistaminic properties. Specific claimed compounds are 1-{3-[4-(diphenylmethoxy)-1-piperidinyl]-propyl}-1,3-dihydro-2H-benzimidaz ol-2-one, 1-{2-[4-(diphenylmethoxy)-1-piperidinyl]ethyl}1-, 3-dihydro-2H-benzimidazol-2-one, and 1-{4-[4-(diphenylmethoxy)-1-piperidinyl]butyl}-1,3-dihydro-2H-benzimidazol -2-one.

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Inventors: Vandenberk, Jan (Beerse, BE)
Kennis, Ludo E. J. (Vosselaar, BE)
Van der Aa, Marcel J. M. C. (Vosselaar, BE)
Van Heertum, Albert H. M. Th. (Vosselaar, BE)

Application Number: 875342
Filing Date: 1978-02-06
Publication_date: 1980-04-29
Assignee: Janssen Pharmaceutica, N.V. (Beerse, BE)
Primary Class(es): 514/318 514/321, 514/322, 544/364, 544/368, 544/370, 546/193, 546/194, 546/198, 546/199, 546/216
Other Classes:
US Patent Ref:

4021564	May, 1977	Hernestam et al.	260/293.
4031226	Jun, 1977	Soudijn et al.	260/293.
4035369	Jul, 1977	Vandenberk et al.	260/293.

Other Refs:
Primary Examiner: Coughlan, Jr., Paul M.
Assistant Examiner:
Attorney: Conte; Salvatore R.