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Primary Examiner: Rollins, Alton D.
Assistant Examiner: Jones, Lisa
Attorney: Ross; Karl F.

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Title: 3-Amino-17a-aza-D-homoandrostane compounds, and pharmaceutical compositions containing them

Abstract: The invention relates to new 3-amino-17a-aza-D-homo-5.alpha.-androstane derivatives of the general formula I ##STR1## wherein R.sub.1 represents a methylene or an >N--CH.sub.3 group, and n stands for 1 or 2, and the acid addition salts and the quaternary salts of the general formula ##STR2## thereof, wherein R.sub.2 stands for an alkyl or alkenyl group having from 1 to 4 carbon atoms, and A represents a halogen atom, provided that if R.sub.1 stands for an >N--CH.sub.3 group, R.sub.2 is attached to the nitrogen of that >N--CH.sub.3 group. The new compound possess a non-polarizing neuromuscular blocking activity and have a short activity period.

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Inventors: Tuba, Zoltan (Budapest, HU)
Marsai, Maria (Budapest, HU)
Gorog, Sandor (Budapest, HU)
Biro, Katalin (Budapest, HU)
Karpati, Egon (Budapest, HU)
Szporny, Laszlo (Budapest, HU)

Application Number: 934799
Filing Date: 1978-08-17
Publication_date: 1980-04-29
Assignee: Richter Gedeon Vegyeszeti Gyar Rt. (Budapest, HU)
Primary Class(es): 514/253.02 514/318, 514/385, 514/422, 514/906, 544/361, 546/77
Other Classes:
US Patent Ref:
Other Refs: Other References: Gandiha, A. et al., J. Pharm. Pharmacol., 1974, vol. 26, pp. 871-877. _
Morrison, R. and R. Boyd, "Organic Chemistry," 3rd ed., Allyn and Bacon, Inc. Boston, 1976, p. 520. _
Muller, Eugen, "Methoden der Organischen Chemie", Houben-Wail-Bond X1/1-Stickstoffverbindungen II Amine, (1957), p. 243. _
Sidgwick, N. "The Organic Chemistry of Nitrogen", Clarendon Press, Oxford, (1966), p. 250. _