Title: Freeze-stable liquid blood control standard

Abstract: A freeze-stable liquid blood control standard and method is provided for the quality control of the measurement of blood pH and gases in the clinical laboratory. The blood control standard comprises a sealed receptacle containing specially treated red cells and a gaseous head space at least equal to about the volume of the red cells. The special treatment comprises thorough washing and separating the red cells from the plasma components and mild treatment with aldehyde, slow admixture with lower aliphatic diol or triol, and retention in a buffered solution. The special treatment optionally includes treating at least a portion of the red cells with carbon monoxide. The head space comprises from 0-15% CO.sub.2, 0-25% O.sub.2 and the balance N.sub.2 and/or inert gas.

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Inventors: Louderback, Allan L. (Temple City, CA, US)
Szatkowski, Paul R. (Bethel, CT, US)

Application Number: 961184
Filing Date: 1978-11-16
Publication_date: 1980-04-22
Assignee:
Primary Class(es): 436/11 436/10, 436/17, 436/18
Other Classes:
US Patent Ref:

3876375	Apr, 1975	Maurukas	23/230.
3973913	Aug, 1976	Louderback	23/230.
4056484	Nov, 1977	Heimburger	252/408.
4116336	Sep, 1978	Sorensen	252/408.
4121905	Oct, 1978	Maurukas	252/408.
4126575	Nov, 1978	Louderback	252/408.

Other Refs:
Primary Examiner: Marantz, Sidney
Assistant Examiner:
Attorney: