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Primary Examiner: Roberts, Elbert L.
Assistant Examiner: Whittenbaugh, Robert C.
Attorney: Sughrue, Rothwell, Mion, Zinn and Macpeak

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Title: Cortisol radioimmunoassay method and cortisol derivatives useful therefor

Abstract: The cortisol compound of the formula (E) ##STR1## wherein R represents a hydroxy group, a tyrosine lower alkyl ester residue, a tyramine residue, a histamine residue, a 7-aminoheptanoyl-tyrosine lower alkyl ester residue, a radioiodinated tyrosine lower alkyl ester residue, a radioiodinated tyramine residue, a radioiodinated histamine residue, a radioiodinated 7-aminoheptanoyltyrosine lower alkyl ester residue, a protein or a polypeptide; and a radioimmunoassay method using cortisol derivative.


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Inventors: Kojima, Masaharu (Fukuoka, JP)
Sone, Hisao (Fukuoka, JP)
Ogawa, Hiroshi (Kashiwa, JP)
Nakazawa, Nobuhiko (Urawa, JP)
Tachibana, Seiji (Tokyo, JP)

Application Number: 802397
Filing Date: 1977-06-01
Publication_date: 1980-02-26
Assignee: Daiichi Radioisotope Laboratories, Ltd. (Tokyo, JP)
Primary Class(es): 552/523
Other Classes:
US Patent Ref:
4031117Jun, 1977Rao260/397.

Other Refs: Other References: Weinstein et al., "Steroids", vol. 20, 1972, pp. 789-809.
Feeser et al., "Steroids" Text, pp. 607 and 650.