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Primary Examiner: Rose, Shep K.
Assistant Examiner:
Attorney: Stone; Robert L., Grill; Murray M., Sylvester; Herbert S.

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Title: Dentifrice for dental remineralization

Abstract: A dentifrice useful for remineralizing subsurface carious lesions of dental enamel which contains sources of calcium ions and phosphate ions as well as fluoride ions and further includes as agent to stabilize against precipitation of the calcium and phosphate ions, an antinucleating agent such as ethylenediamine tetramethylenephosphonic acid or water soluble salt thereof, the pH of the dentifrice being about 5-9, preferably close to physiological conditions, such as about 6.8-7.5.


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Inventors: Gaffar, Maria C. S. (Somerset, NJ, US)
Gaffar, Abdul (Somerset, NJ, US)

Application Number: 020377
Filing Date: 1979-03-14
Publication_date: 1979-12-04
Assignee: Colgate Palmolive Company (New York, NY)
Primary Class(es): 424/52 424/49, 424/54, 424/56, 424/57
Other Classes:
US Patent Ref:
Re29182Apr, 1977McCune et al.424/49.
3288846Nov, 1966Irani et al.260/502.
3298956Jan, 1967Irani et al.260/502.
3336221Aug, 1967Ralston260/502.
3434969Mar, 1969Ralston260/502.
3625569Feb, 1972Medcalf424/48.
3671644Jun, 1972Irani et al.424/329.
3792152Feb, 1974Kim423/311.
3832396Aug, 1974Irani et al.260/502.
4097588Jun, 1978Levine424/52.
4110429Aug, 1978Gaffar et al.424/49.

Other Refs: 16177291515665215950713448151394034
Apr, 1971DE.
Mar, 1968FR.
May, 1978FR.
May, 1974GB.
May, 1975GB.
Other References: Meyer and Nancollas, Calc. Tiss. Res. 13:245-303 (1973), The Influence of Multi-Dentate Phosphonates on the Crystal Growth of Hydroxyapatite.
Briner et al., Calc. Tiss. Res. 7:249-256 (1971), Factors Affecting the Rate of Post-Eruptive Maturation of Dental Enamel.
Monsanto Co. Brochure, "Dequest" Organophosphorus Compounds, Feb. 1971.