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Primary Examiner: Rosen, Sam
Assistant Examiner:
Attorney: Perrella; Donald J., Levitt; Julian S.

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Title: Respiratory syncytial vaccine

Abstract: By serially passaging virulent respiratory syncytial virus in human diploid lung fibroblasts, a non-pathogenic but antigenic live respiratory syncytial virus is produced. This virus is useful in preparing a live virus vaccine.

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Inventors: Buynak, Eugene B. (North Wales, PA, US)
Hilleman, Maurice R. (Lafayette Hill, PA, US)

Application Number: 918760
Filing Date: 1978-06-26
Publication_date: 1979-03-20
Assignee: Merck & Co., Inc. (Rahway, NJ)
Primary Class(es): 435/237
Other Classes:
US Patent Ref:
Other Refs: Other References: law et al., Chem. Abst., vol. 69 (1968) p. 65374u.
Friedewald et al., J. of American Med. Assn., vol. 204, May 20, 1968, pp. 690-694.
Kim et al., Pediatrics, vol. 48, Nov. 1971, pp. 745-755.
McIntosh et al., Pediatric Research, vol. 8 (1974), pp. 689-696.
Wright et al., J. of Pediatrics, vol. 88, Jun. 1976, pp. 931-936.