Title: 20-Hydroxy-prostaglandins

Abstract: The present invention relates to 20-hydroxy prostaglandins of the formula: ##STR1## wherein A represents a grouping of the formula: ##STR2## and X represents ethylene or cis-vinylene and Y represents trans-vinylene, or X and Y each represent ethylene, R represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 12 carbon atoms, R.sup.1 , R.sup.2, R.sup.3, R.sup.4 and R.sup.5, which may be the same or different, each represent a hydrogen atom or a methyl or ethyl group, and n represents zero or an integer from 1 to 3 inclusive, and cyclodextrin clathrates of such acids and esters and, when R represents a hydrogen atom, the non-toxic salts thereof. These compounds exhibit characteristic prostaglandin activity.

Do you think this is a good invention? Vote now:

Votes so far: For:(0) Against:(0)
Other info:

Inventors: Hayashi, Masaki (Takatsuki, JP)
Kori, Seiji (Takatsuki, JP)
Miyake, Hajimu (Suita, JP)

Application Number: 547293
Filing Date: 1975-02-05
Publication_date: 1979-02-20
Assignee: Ono Pharmaceutical Company (Osaka, JP)
Primary Class(es): 562/503 514/826, 514/929, 514/957, 514/962, 549/311, 549/415, 549/421, 560/121, 987/160
Other Classes:
US Patent Ref:

3843713	Oct, 1974	Finch et al.	260/468.
3878239	Apr, 1975	Hayashi et al.	260/514.

Other Refs: 826090

Jun, 1975	BE

Primary Examiner: Gerstl, Robert
Assistant Examiner:
Attorney: Graddis; Albert H., Chow; Frank S.