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Title: D-homopregnanes
Abstract:
D-homopregnanes of the formula ##STR1## wherein R.sup.6 is hydrogen, chloro, fluoro or methyl; X is .beta.-hydroxymethylene or carbonyl; R.sup.17a is hydroxy, lower alkanoyloxy or aroyloxy; R.sup.21 is hydrogen, chloro, fluoro, hydroxy, lower alkanoyloxy, aroyloxy, sulfate or phosphate; and the dotted line in the 1,2-position of the A-ring denotes an additional carbon-carbon bond And pharmaceutically acceptable salts thereof, processes for the preparation thereof and pharmaceutical compositions containing them as the active ingredient are disclosed. The D-homopregnanes of the present invention exhibit hormonal activity and are useful for the treatment of inflammation.
Other info: Inventors: Alig, Leo (Kaiseraugst, CH) Furst, Andor (Basel, CH) Muller, Marcel (Frenkendorf, CH) Kerb, Ulrich (Berlin, DE, US) Wiechert, Rudolf (Berlin, DE, US) Application Number: 898070 Filing Date: 1978-04-20 Publication_date: 1978-12-26 Assignee: Hoffman-La Roche Inc. (Nutley, NJ) Primary Class(es): 558/178 546/263, 546/285, 558/92, 560/43, 560/61, 560/62, 560/64, 560/65, 560/107, 560/194, 560/257, 568/348, 568/372 Other Classes: US Patent Ref:
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