Title: Structured orthoester and orthocarbonate drug delivery devices

Abstract: The invention concerns orthoester and orthocarbonate polymers having a repeating mer comprising a hydrocarbon radical and a symmetrical dioxycarbon unit of the general formula: ##STR1## WHEREIN R.sub.1 is a multivalent hydrocarbon radical, R.sub.2 and R.sub.3 are hydrocarbon radicals with at least one of R.sub.2 or R.sub.3 bonded to the dioxycarbon through an oxygen linkage, and which polymers are synthesized by reacting a polyol with an orthoester or orthocarbonate. The polymers are useful for making articles of manufacture, including devices and coatings for delivering beneficial agents.

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Inventors: Choi, Nam S. (Seoul, KR)
Heller, Jorge (Palo Alto, CA, US)

Application Number: 882814
Filing Date: 1978-03-02
Publication_date: 1978-12-26
Assignee: Alza Corporation (Palo Alto, CA)
Primary Class(es): 424/484 71/64.11, 71/64.13, 128/832, 264/4.3, 264/4.6, 424/422, 424/427, 424/436, 427/213.3, 428/402.24, 504/360
Other Classes:
US Patent Ref:

4001388	Jan, 1977	Shell	424/14.
4093709	Jun, 1978	Choi et al.	424/19.

Other Refs:
Primary Examiner: Rose, Shep K.
Assistant Examiner:
Attorney: Sabatine; Paul L., Ciotti; Thomas E., Mandell; Edward L.