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Primary Examiner: Schenkman, Leonard
Assistant Examiner:
Attorney: Clarke; Kevin B.

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Title: Method for suppressing histamine release

Abstract: A method for suppressing the release of histamine from sensitized leukocytes in warm blooded animals which comprises administering internally to said animals compounds of the formula: ##STR1## wherein n is a whole integer from 1 to 4; X is halogen and Z is COOH, CH.sub.2 OR or ##STR2## R being a lower alkyl chain of from 1 to 6 carbon atoms and pharmaceutically acceptable salts of those compounds wherein Z is COOH, in sufficient amount to suppress the release of histamine from said cells.

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Other info:

Inventors: Reisner, David B. (Hightstown, NJ, US)
Ludwig, Bernard J. (North Brunswick, NJ, US)
Fukui, George M. (Princeton, NJ, US)
Berger, Frank M. (New York, NY, US)

Application Number: 770062
Filing Date: 1977-02-18
Publication_date: 1978-11-07
Assignee: Carter-Wallace, Inc. (New York, NY)
Primary Class(es): 514/568 514/712
Other Classes:
US Patent Ref:

3651236	Mar, 1972	Kelly et al.	424/317.
3879544	Apr, 1975	Reisner et al.	424/337.

Other Refs: Other References: Chemical Abstracts 67: 90489b (1967).