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Title: Transient pro-drug forms of phenylbutazone
Abstract:
Novel, transient pro-drug forms of the anti-inflammatories phenylbutazone and oxyphenbutazone are disclosed, the same having the structural formulae: ##STR1## wherein R is a member selected from the group consisting of C.sub.1 -C.sub.2 alkylsulfonyl, phenylsulfonyl, p-tolylsulfonyl and naphthylsulfonyl, and ##STR2## wherein X and Y each represent a member selected from the group consisting of a hydrogen atom and ##STR3## with the proviso that either X or Y is a hydrogen atom, R.sub.1 is selected from the group consisting of C.sub.1 -C.sub.2 alkylsulfonyl, phenylsulfonyl, p-tolylsulfonyl and naphthylsulfonyl, and R.sub.2 is selected from the group consisting of straight or branched chain C.sub.1 -C.sub.5 alkyl and phenyl.
Other info: Inventors: Bodor, Nicolae S. (Lawrence, KS, US) Sloan, Kenneth B. (Lawrence, KS, US) Application Number: 777074 Filing Date: 1977-03-14 Publication_date: 1978-09-26 Assignee: INTERx Research Corporation (Lawrence, KS) Primary Class(es): 548/367.1 Other Classes: US Patent Ref:
Other Refs: Other References: Gimbert, et al., Chem. Abs., vol. 77, 1972, 34511x. Sala, et al., Chem. Abs., vol. 68, 1968, 95751m. | |