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Primary Examiner: Schenkman, Leonard
Assistant Examiner:
Attorney: Boland; Thomas R.

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Title: Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes

Abstract: Pharmaceutical vehicles for delivery of pharmacologically active chemical materials to mucous membranes, as well as pharmaceutically active compositions containing such vehicles, are provided. The pharmaceutical vehicles are clear, water-miscible, physiologically-acceptable, liquid compositions which gel to a thickened, non-flowing and adhering consistency at human body temperature. They are liquid at ambient room temperature and have a gel transition temperature in the range of from about 25.degree. to about 40.degree. C. Aqueous solutions of certain polyoxyethylene-polyoxypropylene condensates are suitable vehicles. Also provided are pharmaceutical compositions containing added pharmacologically active chemical material, i.e., a drug or medicament. A method of delivering the drug or medicament to a mucous membrane is also provided.

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Other info:

Inventors: Krezanoski, Joseph Z. (Los Altos, CA, US)

Application Number: 661612
Filing Date: 1976-02-26
Publication_date: 1978-07-11
Assignee: Cooper Laboratories, Inc. (Parsippany, NJ)
Primary Class(es): 514/11 514/21, 514/31, 514/32, 514/39, 514/40, 514/155, 514/180, 514/250, 514/397, 514/628, 514/653
Other Classes:
US Patent Ref:

2921885	Jan, 1960	Bonchal	167/93.
3240709	Mar, 1966	Rankin	252/106.
3639574	Feb, 1972	Schmolka	424/78.
3740421	Jun, 1973	Schmolka	424/78.
3767788	Oct, 1973	Rankin	424/78.
3867533	Feb, 1975	Schmolka	424/78.
3882036	May, 1975	Krezanoski et al.	424/78.
3884826	May, 1975	Phare, Jr. et al.	424/78.
3947573	Mar, 1976	Rankin	424/78.

Other Refs: Other References: Wyandotte Corp., "The Wonderful World of Pluronic Polyols", (1973).