Title: Inert core implant pellet

Abstract: A novel spherical implant pellet containing estradiol, estradiol benzoate, or mixtures thereof as the sole active ingredients which exhibits a substantially constant drug release rate over a timer period and substantially abrupt termination of drug release at the end of the time period is prepared which has an inert spherical core of a diameter of about 2-10 mm and a uniform coating of about 0.05-1 mm completely covering the core, the coating comprising about 5-99% suitable carrier and 1-95% drug. A drug may be administered at a constant rate over a chosen period by implanting the novel pellet and the release is substantially abruptly terminated at the end of said period without removing the pellet.

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Inventors: Katz, Martin (Los Altos Hills, CA, US)
Kent, John S. (Palo Alto, CA, US)

Application Number: 735727
Filing Date: 1976-10-26
Publication_date: 1978-06-20
Assignee: Syntex Corporation (PM)
Primary Class(es): 424/426 514/953
Other Classes:
US Patent Ref:

RE28536	Sep, 1975	Reed	128/264.
2921883	Jan, 1960	Reese et al.	424/35.
3443561	May, 1969	Reed	128/260.
3499445	Mar, 1970	Reed	128/260.

Other Refs:
Primary Examiner: Rose, Shep K.
Assistant Examiner:
Attorney: Moran; Tom M., Walker; William B.