Title: Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates)

Abstract: The invention concerns orthoester and orthocarbonate polymers having a repeating mer comprising a hydrocarbon radical and a symmetrical dioxycarbon unit of the general formula: ##STR1## WHEREIN R.sub.1 is a multivalent hydrocarbon radical, R.sub.2 and R.sub.3 are hydrocarbon radicals with at least one of R.sub.2 or R.sub.3 bonded to the dioxycarbon through an oxygen linkage, and which polymers are synthesized by reacting a polyol with an orthoester or orthocarbonate. The polymers are useful for making articles of manufacture, including devices and coatings for delivering beneficial agents.

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Inventors: Choi, Nam Sok (Seoul, KS, US)
Heller, Jorge (Palo Alto, CA, US)

Application Number: 544808
Filing Date: 1975-01-28
Publication_date: 1978-06-06
Assignee: Alza Corporation (Palo Alto, CA)
Primary Class(es): 424/424 424/426, 424/427, 424/433, 424/436, 424/484, 424/486
Other Classes:
US Patent Ref:

3887699	Jun, 1975	Yolles	128/260.
3960150	Jun, 1977	Hussain	424/19.
4001388	Jan, 1977	Shell	424/19.
4014987	Mar, 1977	Heller	424/19.

Other Refs:
Primary Examiner: Jiles, Henry R.
Assistant Examiner: Owens, Cary
Attorney: Sabatine; Paul L., Ciotti; Thomas E., Mandell; Edward L.