Title: Aminoethyl oximes having anti-depressive activity

Abstract: The compounds of the formula ##STR1## where Hal is Br or Cl and R is ethoxy, methoxymethyl, ethoxymethyl, cyano, methoxyethoxy or cyanomethyl when Hal is Cl and is cyano, methoxy or methoxyethoxy when Hal is Br and their salts have a strong anti-depressive activity resulting in a powerful potentiation of noradrenalin and in a strong serotonin potentiation. Monoamino oxidase inhibition does not provide a basis for the antidepressive activity of these compounds. The compounds are free from noxious side effects to a considerable extent, for example, broncho-constriction and stomach ulceration.

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Inventors: Welle, Hendricus Bernardus Antonius (Utrecht, NL)
Claassen, Volkert (Weesp, NL)

Application Number: 668479
Filing Date: 1976-03-19
Publication_date: 1978-04-25
Assignee: U.S. Philips Corporation (New York, NY)
Primary Class(es): 514/523 514/640, 558/408, 562/595, 564/256
Other Classes:
US Patent Ref:

3692835

Sep, 1972

Van Dijk et al.

260/566.

Other Refs:
Primary Examiner: Torrence, Dolph H.
Assistant Examiner:
Attorney: Trifari; Frank R., Spain; Norman N.