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Primary Examiner: Phillips, Delbert R.
Assistant Examiner:
Attorney: Raines; Stephen, Chow; Frank S., Ehrlinger; David B.

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Title: Hexapeptides and methods for their production

Abstract: New hexapeptides having the formula X-R-Trp-His(benzyl)-Tyr(benzyl)-Ser(benzyl)-R.sup.1 -Ala-Y wherein X is t-butoxycarbonyl or benzyloxycarbonyl, R is a single bond, His, His(benzyl) or Gln; R.sup.1 is a single bond or Pro and Y is lower alkoxy, amino, lower alkylamino or di(lower alkyl)amino with the proviso that the total number of amino acid units when R and R.sup.1 are combined is one.

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Inventors: Tinney, Francis John (Ann Arbor, MI, US)
Nicolaides, Ernest D. (Ann Arbor, MI, US)

Application Number: 723370
Filing Date: 1976-09-15
Publication_date: 1978-04-18
Assignee: Parke, Davis & Company (Detroit, MI)
Primary Class(es): 530/329 514/800, 930/21, 930/130, 930/DIG698, 930/DIG802
Other Classes:
US Patent Ref:

3855238

Dec, 1974

Batesky et al.

260/112.

Other Refs: Other References: Schroder et al., The Peptides, vol. I, 1965, Academic Press, New York, pp. 109-111.
Roberts and Caserio, Basic Principles of Org. Chem., Benjamin Inc., 1965, pp. 531, 563-564.
Stewart et al., Solid Phase Peptide Synthesis, Freeman & Co., San Francisco, 1969, p. 12.