Title: Clottable fibrinogen free Factor VIII product and process

Abstract: Lyophilizable, clottable fibrinogen free, Factor VIII is produced on a commercial scale from a fibrinogen containing Factor VIII concentrate by sequentially, precipitating a major portion of the clottable fibrinogen by the addition of an ethylene oxide-polyoxypropylene block copolymer, clotting the remainder of the clottable fibrinogen by the addition of a small amount of a thrombin mimetic enzyme which does not decrease the potency of the Factor VIII, and adding human albumin to the resultant clottable fibrinogen free Factor VIII to stabilize its potency during lyophilization.

Do you think this is a good invention? Vote now:

Votes so far: For:(0) Against:(0)
Other info:

Inventors: Bick, Rodger L.
Fekete, Lajos F. (Costa Mesa, CA, US)

Application Number: 750849
Filing Date: 1976-12-15
Publication_date: 1978-04-18
Assignee: Bick; Rodger L. (Bakersfield, CA); Fekete; Lajos F. (Bakersfield, CA); Wilson; William L. (Santa Monica, CA)
Primary Class(es): 530/383 530/362, 530/363, 530/382, 530/830
Other Classes:
US Patent Ref:

3973002	Aug, 1976	Hagan et al.	260/112.
4022758	May, 1977	Andersson et al.	260/112.

Other Refs: Other References: Kevy, Chemical Abstracts, vol. 78: 69,608g, (1973).