Title: Drug-delivery device comprising certain polymeric materials for controlled release of drug

Abstract: Drug-delivery device for releasing a drug at a continuous and controlled rate for a prolonged period of time is comprised of a shaped body of polymeric material containing a pharmaceutically acceptable drug and permeable to passage of the drug by diffusion. The polymeric material is an ethylene-vinyl acetate copolymer having a vinyl acetate content of about 4 to 80% by weight and a melt index of about 0.1 to 1000 grams per 10 minutes.

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Inventors: Higuchi, Takeru (Lawrence, KS, US)
Hussain, Anwar (Lawrence, KS, US)

Application Number: 582353
Filing Date: 1975-05-30
Publication_date: 1978-01-17
Assignee: Alza Corporation (Palo Alto, CA)
Primary Class(es): 424/432 424/422, 424/427
Other Classes:
US Patent Ref:

3011949	Dec, 1961	Bilotti	424/48.
3710795	Jan, 1973	Higuchi et al.	128/260.
3737521	Jun, 1973	Born	424/22.
3854480	Dec, 1974	Zaffaroni	128/260.

Other Refs: 1,505,267

Dec, 1967	FR.

Primary Examiner: Rose, Shep K.
Assistant Examiner:
Attorney: Sabatine; Paul L., Goldby; Steven D.