Title: Polymeric orthoesters housing beneficial drug for controlled release therefrom

Abstract: This invention concerns polymeric orthoesters having a repeating mer comprising a hydrocarbon radical and an orthoester functionality of the general formula: ##STR1## wherein R.sub.1 is a monovalent radical, R.sub.2 is a hydrocarbon radical, a is 2 to 3, and n is at least 10. The polymers are useful for making articles of manufacture and as coatings for beneficial agents.

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Inventors: Capozza, Richard C. (Palo Alto, CA, US)

Application Number: 675185
Filing Date: 1976-04-08
Publication_date: 1978-01-03
Assignee: Alza Corporation (Palo Alto, CA)
Primary Class(es): 514/166 514/161, 514/304, 514/312, 514/317, 514/327, 514/397, 514/535, 514/619, 514/626, 514/653, 514/654, 528/271, 528/403, 528/405, 528/425
Other Classes:
US Patent Ref:

3887699	Jun, 1975	Yolles	424/78.
3911098	Oct, 1975	Capozza	424/22.
3914402	Oct, 1975	Shell	424/32.

Other Refs:
Primary Examiner: Schenkman, Leonard
Assistant Examiner:
Attorney: Sabatine; Paul L., Ciotti; Thomas E., Mandell; Edward L.