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Title:
Ocular therapeutic system with selected membranes for administering ophthalmic drug
Abstract:
An ocular therapeutic system for releasing a drug to the eye at a controlled and continuous rate for a prolonged period of time is disclosed. The system is shaped, sized and adapted for insertion and retention in the eye. The system contains an ophthalmically acceptable drug and it is formed of a polymeric material permeable to the passage of drug by diffusion. The material is an ethylene-vinyl ester copolymer of the general formula: ##STR1## WHEREIN R is hydrogen, alkyl of 2 to 7 carbons, or aryl, m is (4 to 80)% by weight and n is (100 - m)% by weight.
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Inventors:
Higuchi, Takeru (Lawrence, KS, US) Hussain, Anwar (Lexington, KY, US)
Application Number:
705470
Filing Date: 1976-07-15 Publication_date: 1977-11-08 Assignee:
Alza Corporation (Palo Alto, CA)
Primary Class(es):
424/427
Other Classes:
US Patent Ref:
Other Refs:
569,927| Jun, 1945 | UK. | | 582,093Nov, 1946 | UK. | | | | | | | |
Other References:
Raff et al., Crystalline Olefin Polymers, Raff et al., part II, pp. 261-266 (1964). |