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Primary Examiner: Rose, Shep K.
Assistant Examiner:
Attorney: Sabatine; Paul L., Ciotti; Thomas E., Mandell; Edward L.

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Title: Ocular therapeutic system with selected membranes for administering ophthalmic drug

Abstract: An ocular therapeutic system for releasing a drug to the eye at a controlled and continuous rate for a prolonged period of time is disclosed. The system is shaped, sized and adapted for insertion and retention in the eye. The system contains an ophthalmically acceptable drug and it is formed of a polymeric material permeable to the passage of drug by diffusion. The material is an ethylene-vinyl ester copolymer of the general formula: ##STR1## WHEREIN R is hydrogen, alkyl of 2 to 7 carbons, or aryl, m is (4 to 80)% by weight and n is (100 - m)% by weight.


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Inventors: Higuchi, Takeru (Lawrence, KS, US)
Hussain, Anwar (Lexington, KY, US)

Application Number: 705470
Filing Date: 1976-07-15
Publication_date: 1977-11-08
Assignee: Alza Corporation (Palo Alto, CA)
Primary Class(es): 424/427
Other Classes:
US Patent Ref:
2200429May, 1940Perrin et al.526/235.
2396785Mar, 1946Hanford526/232.
2947735Aug, 1960Bartl526/212.
3710795Jan, 1973Higuchi et al.128/260.
3854480Dec, 1974Zaffaroni128/260.

Other Refs: 569,927582,093
Jun, 1945UK.
Nov, 1946UK.
Other References: Raff et al., Crystalline Olefin Polymers, Raff et al., part II, pp. 261-266 (1964).